Solve the deep root cause of osteoarthritis with glucosamine sulfate.

Osteoarthritis
         is a common joint disorder tends to occur in the Middle Ages and increase with age. It most commonly affects the weight-bearing joints such as knees, hips, spine, etc.    
 

   Cause of osteoarthritis. 
        Osteoarthritis is caused by decreased cartilage in the joints. Typically, articular cartilage functions as a shock absorber in the joint and prevents the bone under the cartilage from colliding against each other. If these articular cartilage is reduced for any reason, the weight or pressure exerted on the joint will result in the unprotected bones under the cartilage surface start to rub against each other, the muscles and ligaments surrounding the joint are stretched, followed by pain.

Risk factors for osteoarthritis include:
     1.  Age
        With increasing age, there is an increasing chance of developing osteoarthritis due to less cartilage production. 
          
     2.  Overweight
         Being overweight will directly result in increased intra-articular pressure that carries additional weight.

     3.  Some activities in daily life.
          Daily life including various habitual behaviors that result in excessive pressure on the joints e.g., kneeling or sitting with legs to the side. 

   4.  Genetic factor
          Especially, in families with a history of weak joints and cartilage. 

        Clinical manifestations of osteoarthritis
         1.  Pain is characterized by dull, unspecific generalized pain around the joint area, unable to determine the exact location and often chronic. The pain is more pronounced when in used or increase weight on the joint and will subside with rest. As the disease progresses, it can cause constant pain or pain during the night.
         2.  Stiffness is common. Joint stiffness may occur in the morning and after prolonged resting or immobility.
         3.  Swollen and deformed joints may experience a buckling of the leg.  Swollen joints are swellings from bone spurs around the joints. 
         4.  Loss of joint movement and functions. The patient has difficulty walking or is unable to pick up things easily.
         5.  A rustling sound in the joints while moving especially at the. knee


    Recommendations for people with osteoarthritis.     
           Control body weight within the standard range.
           Use a walking stick to help when traveling long distances.
           Regularly exercise the muscles around the joints.
           Avoid postures that require heavy exertion on the joints, such as squatting, cross-legged, or sitting with the leg on the side.      

    Osteoarthritis Treatment Guidelines
           Joint replacement surgery performed by a doctor in severe cases.
           Physical therapy including exercises to strengthen the muscles around the joints.
           Medications include medications that relieve pain e.g., pain relievers, non-steroidal anti-inflammatory drugs (NSAIDs) which is a drug used only when the pain is presented, as it has side effects that increase the risk of gastrointestinal ulcers.
           Drugs that strengthen and inhibit the destruction of articular cartilage include glucosamine sulfate, a drug that corrects the underlying cause of osteoarthritis.

    Glucosamine sulfate, solves the root cause of osteoarthritis.
            'Glucosamine' is a substance found in the body. It is a fundamental component of cartilage synthesis called glycosaminoglycan. But with age, less glucosamine is produced and more is broken down by enzymes such as collagenase, causing the degeneration of articular cartilage. Currently, glucosamine sulfates are commonly used in people with osteoarthritis as medical research has shown that glucosamine sulfate helps correct the root cause of osteoarthritis by its important properties, including: 
           It is an important basic component of articular cartilage. 
           It stimulates the production of articular cartilage.
           It inhibits an enzyme that destroys cartilage, such as collagenase.

    Glucosamine sulfate, and pain relief.
         When taken for at least 2 weeks, the pain relief is comparable to non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and piroxicam, but with significantly fewer side effects on irritation and ulceration of the gastrointestinal tract.  However, during the first 2 weeks, the patient may need to take non-steroidal anti-inflammatory drugs as needed along with taking glucosamine sulfate.     
 
    Recommended dose:  
          1,500 milligrams per day for at least 4-8 weeks